"Penny" and "Leonard" from The Big Bang Theory did not only hook up on-screen, but fell in love in real life as well. However, Kaley Cuoco and Johnny Galecki kept their relationship a secret until they separated in 2010. Johnny is now dating Ariella Nicole, while Kaley is engaged to Karl Cook.
Rachel Billson and Adam Brody met on the set of The O.C. in 2003 and fell for each other. They were together for three years until 2006. As it turns out, they weren’t right for each other, but have both found their match by now. Rachel has been in a relationship with Hayden Christensen since 2008 and they have a daughter together. Adam Brody has been married to Leighton Meester since 2014.
Kit Harington has been in an on-and-off relationship with Game of Thrones co-star Rose Leslie since 2012, which was also the year her character was introduced to the HBO show. By now, they are definitely "on" and engaged.
After having dated Zach Braff, the Scrubs star and producer, for two years, she had a small part on two episodes of Scrubs. The couple separated in 2006, and Mandy is now dating musician Taylor Goldsmith. Zach Braff is single.
The Vampire Diaries actors Ian Somerhalder and Nina Dobrev also fell in love on set. They separated in 2013 after three years. Ever since, Somerhalder has gotten married to Twilight star Nikki Reed and the couple welcomed their first child. Nina Dobrev is currently single.
Kat Dennings and Nick Zano got together in 2011 while shooting Two Broke Girls and were together for three years. After they broke up in 2014, Kat started dating musician and producer Josh Groban - she is currently single. Nick has been with his girlfriend Leah Renee since 2014.
Jessica Szohr and Ed Westwick had a love affair not only in front of the camera. They dated for two years in real life, from 2008 to 2010. Jessica started dating her current boyfriend Scotty McKnight in 2014, Ed Westwick is single.
Charmed-stars Alyssa Milano and Eric Dane also dated off-screen for a while in 2003. Eric got married to actress Rebecca Gayheart in 2004, they have two kids together but got divorced in 2018. Alyssa married her former agent Dave Bugliari in 2009 and they are still together as well.
Katie Holmes and Joshua Jackson starred as "Joey" and "Pacey" in Dawson's Creek and also fell for each other in real life. Too bad their love only lasted for one season, from 1998 to 1999, while the show went on for six. Jackson is single these days, while Katie is dating the actor Jamie Foxx.
Emily VanCamp has been dating Revenge co-star Josh Bowman since 2011 and they got engaged in May of 2017.
Courteney Cox and Brian Van Holt played a divorced couple in the popular TV show Cougar Town. Although the show lasted for a total six seasons, their relationship was unfortunately only good for one year.
Milo Ventimiglia and Alexis Bledel fell in love on the Gilmore Girls set. They dated from 2002 to 2006. Milo is currently single, while Alexis has been married to fellow actor Vincent Kartheiser since 2014.
Blake Lively and Penn Badgley starred together in Gossip Girl. From 2007 to 2010, "Serena" and "Dan" also dated in real life. Blake Lively has been married to the Deadpool star Ryan Reynolds in 2012, Penn Badgley and his wife were married in Februar 2017.
Sophia Bush and Chad Michael Murray met on the set of One Tree Hill and they got engaged in 2004, but six months after their wedding they already got divorced. These days, Sophia is single Chad Michael Murray is married to actress Sarah Roemer, the couple has two children.
Jennifer Garner and Michael Vartan starred together in Alias. They were together for only one year. Like Michael Vartan, Jennifer Garner is single these days and has famously been married to Ben Affleck from 2005 to 2015.
Ginnifer Goodwin and Josh Dallas met during the filming of the popular ABC show Once Upon a Time. "Snow" and "Charming" started dating in 2011, got married in 2014 and they have two kids together. A real-life fairytale!