The role of "Meredith Grey" the really big breakthrough for Ellen Pompeo. At that time she was already 34 years old even though her character in Grey's Anatomy was roughly only 28 when she started as an intern in the surgical program at the hospital which was then still called "Seattle Grace".
Now, the actress still wows her audience. Pompeo signed a new contract for her role in Grey's Anatomy in 2015, making her one of the 10 highest paid women in television!
Patrick Dempsey's "Dr. Derek Shepherd", whom everyone just called "McDreamy" after the first couple of episodes, started enchanting the fans of ABC's hit medical drama Grey's Anatomy when it premiered in 2005...
Dempsey's mane is slightly more grey by now, but he's still quite an attractive man! He exited the show with the end of the eleventh season when "McDreamy" died a heart-breaking TV death. In 2016, he appeared as "Jack Qwant" in Bridget Jones's Baby, but mainly (as the picture suggests) he dedicates most of his spare time to race car driving and taking care of his family - he has been married to his second wife since 1999 and they have three children.
Justin Chambers has been on board of the Grey's Anatomy train since the first episode. He plays the eccentric "Alex Karev"...
... Chambers has not changed much over the years and certainly does not look his age (end of his forties). He is still an integral part of the show - "Alex" and "Meredith" are best friends by now!
Sandra Oh was part of the main cast from the beginning and played "Dr Christina Yang" for ten years. It was a shock to many fans when she left the show!
By now, the actress is in her later forties and most recently had a recurring role in the third season of ABC's drama American Crime. She played "Abby Tanaka", a social worker who runs a shelter in Alamance County, N.C., for victims of domestic abuse.
Chandra Wilson, alias "Dr. Miranda Bailey" has also been part of the main cast since the first day of shooting in 2004!
Actress Chandra Wilson originally comes from Texas and is still one of the pillars of the show and has been for all the seasons now!
Sara Ramirez alias "Kelly Torres" in 2006.
...Ramirez is still a gorgeous woman! She joined the cast as a recurring character with the beginning of the second season and became part of the main cast until the end of the twelfth season. Ramirez played "Dr. Calliope 'Kelly' Torres" for a total of 238 episodes!
Also, James Pickens belongs to the master crew. He played "Dr. Webber" for over nine years.
He might have aged, but with grace! James Pickens still looks great and there seems no end in sight for his role in Grey's Anatomy!